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The Mechanism of Accommodation and Presbyopia


written by: R.A. Schachar

Price: € 115.00 / US $ 143.75

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Publication details: Book. 2012. xii and 266 pages. Publication date: 2012-10-23. many full color illustrations. Hardbound with dusk jacket. 16x24 cm (6.3x9.4 in).

ISBN: 978-90-6299-233-1 (ISBN 10: 90-6299-233-1; Kugler Publications)

Also available as ebook

Preface

Preface

This book is a compilation of 25 years of work. Readers will gain an in-depth understanding of the mechanism of accommodation. The investigator will learn the challenges and pitfalls of performing accommodative experiments. Critical thinking, an unbiased view and an open mind, will enable readers to appreciate the beauty and efficiency of the accommodative mechanism and its relationship to other physiological and physical phenomena.

 This work is an exciting academic challenge. From basic experiments to sophisticated mathematical and physical analyses, constructing a final path toward understanding accommodation and presbyopia has been intellectually rewarding. Reaching that final path was possible only with the dedication of my wife, Kathy, and my children, Ira, Elise, Eli, Leah, and Asa, who contributed in numerous ways, including editing text and writing computer programs.

I am indebted to my loyal, best friend Norman S. Levy, M.D., Ph.D., who understood the intricacies of the project, was able to keep me focused, and made me reevaluate each step of the way. He spent considerable time editing, discussing, and evaluating each new finding. I cannot thank him enough for volunteering precious time from his ophthalmic practice, research, and family.

A special thanks to professors: Truman D. Black, Ph.D., "Leo" Tseng Huang, Ph.D. (1925-2006), Dale A. Anderson, Ph.D., Farhad Kamangar, Ph.D., Ali Abolmaali, Ph.D., Guojun G. Liao, Ph.D., Zdzslaw Musielak, Ph.D., George Rosensteel, Ph.D., Roger W. Chan, Ph.D., and their graduate students: Donald P. Cudmore, M.S., Russell Torti, Ph.D., Victor W. Shung, Ph.D., Chang-Hai "Michael" Chien, Ph.D., Tri Le, Ph.D., and Roger D. Kirby, Ph.D. for their insights, loyalty, and willingness to work at all hours to perform difficult experiments and solve arduous problems.

 Without the support, laboratory time, and coauthorship of the following investigators, none of the new findings and insights would have been possible:

Andrew J. Bax, M.S., P.E. Ryan T. Mckinney
Wickham Chen Robert Ritch, M.D.
Carlos Davila, Ph.D. Jannick P. Rolland, Ph.D.
Deborah K. Fygerson, Ph.D. David J. Schanzlin, M.D.
Xin Huang, Ph.D. Victor W. Shung, Ph.D.
Roger L. Kash Celso Tello, M.D.
Annemari Koivula, M.D. Russell Torti, Ph.D.
Frank L. Lewis, Ph.D. Warren W. Ward
Jeffrey M. Liebmann, M.D. James C. Wyant, Ph.D.

I wish to acknowledge the editors of the British Journal of Ophthalmology, Randall T. Bellows, M.D., editor of Annals of Ophthalmology, and Mitchell H. Friedlaender, M.D. (1946-2011), editor of International Ophthalmology Clinics, for their diligence in insuring unbiased peer review and objective evaluation. Their publication of the challenging and new concepts reflects the responsible leadership, editorial excellence, and foresight each has provided to their respective journals.

Finally, I reserve special thanks for Barbara K. Pierscionek, Ph.D. for her willingness to challenge the status quo, to maintain an open mind, and her unwavering curiosity and commitment to scientific truth.

This whole endeavor has been and continues to be fun!

Ron Ronald A. Schachar, M.D., Ph.D.
P.O. Box 8669
La Jolla, CA 92038
T: 858 784-1705
E: ron@2ras.com

Introduction

Introduction

The human eye is a remarkable optical device. In less than a second, a young human eye can accommodate from infinity to closer than 10 cm. Accommodation occurs with minimal effort and can be rapidly repeated with no apparent evidence of fatigue. Unfortunately, maximum accommodation decreases throughout life and by the fifth decade leads to presbyopia, the inability to read at a normal working distance. Interestingly, the mechanism by which the human eye is able to adjust focus has been debated for over 300 years. No previous theory has been put forth that can account for all the physical changes known to occur during accommodation.

Accommodation occurs as a consequence of a change in shape of the lens of the eye. The key changes during accommodation are central surface steepening combined with peripheral surface flattening, a shape that I refer to as the "steep profile". In this treatise, I employ mathematics, physics, mechanics, physiology, and anatomy to fully explain the mechanism of accommodation.

The book begins with a short introduction to accommodation and its present theories. Readers are then introduced to the mathematical analysis of an ellipse and the changes that occur in its shape when its major axis is increased under constraints that simulate the human lens during accommodation. This approach is taken to demonstrate that the shape of the accommodated lens is just one manifestation of a fundamental and universal phenomenon, the steep profile. This basic understanding is then used to predict the amplitude of accommodation of different vertebrates. Next, the anatomy and physiology basic to the accommodative mechanism are investigated and the experimental evidences supporting and contradicting the steep profile mechanism are evaluated. Then, sophisticated mathematical and finite element analyses are applied to fully describe the major parameters that affect accommodation and its age-related decline, which results in the universal manifestation of presbyopia in the fifth decade of life. This is followed by a discussion of the experimental controls required to observe the accommodative mechanism. In an example of the universality of the steep profile phenomenon, the implications of steep profile formation on lenticular galaxy evolution are presented. The book concludes with a summary of findings that must be observed during accommodative experiments. Included in the appendices is a MATLAB software program for demonstrating a steep profile in an ellipse and complete copies of pertinent published papers.

Table of Contents

Preface
Introduction

1. History of Accommodation and the Steep Profile

1.1 Helmholtz's theory of accommodation is flawed
1.2 Tscherning's theory of accommodation is flawed

2. Mechanism of Accommodation

2.1 The steep profile in a two-dimensional ellipse
2.2 Demonstration of steep profiles
2.3 General requirements for steep profile formation

3. Aspect Ratio of Vertebrate Lenses Predicts Accommodative Amplitude

4. Anatomy and Physiology

4.1 Lens
4.2 Lens growth
4.3 Lens capsule
4.4 Zonules
4.5 Ciliary muscle
4.6 Ciliary muscle-A mechanical servo-system
4.7 Ciliary muscle-Zonular function
4.8 Age-related ciliary muscle changes
4.9 Ciliary muscle force

5. Experimental Evidence

5.1 Steepening of anterior and posterior central lenticular surfaces during accommodation
5.2 Increase in central lenticular thickness during accommodation
5.3 Negative shift in spherical aberration during accommodation
5.4 Isolated fresh in vitro human lenses are unaccommodated
5.5 Traction on the human lens equator results in a steep profile
5.6 Lens is stable during accommodation
5.7 The empty lens capsule during accommodation
5.8 Stress on anterior lens capsule during accommodation

6. Mathematical Modeling of Accommodation

6.1 Material properties
6.2 Material properties of the human lens
6.3 Classical analytical methods
6.4 Finite element analysis
6.5 Evaluation of published finite element studies

7. Presbyopia and Age-related Ocular Hypertension

7.1 Presbyopia
7.2 Options for physiologically correcting and/or preventing presbyopia
7.3 Lens growth leads to the age-related increase in intraocular pressure

Importance of Controlled Studies

8.1 Magnetic resonance imaging of accommodation
8.2 Photographic techniques
8.3 Ultrasound biomicroscopic techniques
8.4 Computer image analysis
8.5 Pupil not a proper positional reference
8.6 Optical coherence tomography

9. The Steep Profile: A Fundamental Structure in the Universe

9.1 Hubble's categorization of galaxies
9.2 Jeans' explanation of the Hubble tuning fork
9.3 Lenticular galaxy formation
9.4 Evolution of lenticular galaxies into spiral galaxies

10. Summary

References

Appendix I: Computer program: Ellipse to steep profile
Appendix II: Deformation analysis of ciliary muscle contraction
Appendix III: Linear mathematical analysis of accommodation
Appendix IV: Equation for describing the lens
Appendix V: Nonlinear mathematical analysis of accommodation
Appendix VI: Nonlinear finite element analysis of accommodation
Appendix VII: Nonlinear finite element sensitivity analysis of accommodation
Appendix VIII: Surgically increasing the amplitude of accommodation
Appendix IX: Treatment of ocular hypertension
Appendix X: Ultrasound biomicroscopy of human accommodation
Appendix XI: Ultrasound biomicroscopy of nonhuman primate accommodation
Appendix XII: Computer analysis of nonhuman primate accommodation
Appendix XIII: Evolution of lenticular galaxies

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