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Glaucoma Research and Clinical Advances

2016 to 2018

edited by: P.A. Knepper & J.R. Samples

Price: € 90.00 / US $ 100.00

ISBN 10: 90-6299-247-1
ISBN 13: 978-90-6299-247-8
Publisher: Kugler Publications
Publication date: 2016-02-23
Publication type: Book
Publication details: 2016. x Hardbound. Letter format, with many full color figures.

This volume was conceived as a recurring project. It is neither book nor journal. Books are infrequently edited and rarely up-to-date for more than a year or two; journals are really devoted to the standard experimental format and no longer permit authors to wander into speculation or lengthy discussions of what might come next. There is room for a plurality of publishing approaches. All of these formats have their place and all have different purposes in moving a field forward. Our volume is designed allow us to consolidate new information and hold forth on speculation in glaucoma. It does so in both the basic sciences and clinical sciences. It is our hope that this consolidation of hypotheses and theories, along with identifying new information and new speculation will propel us toward a more rapid cure for glaucoma. It will be refined and updated over the years to come to keep it the most essential of all references.

This publication is part of the New Concepts in Glaucoma series

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Introduction

This first volume in the New Concepts In Glaucoma Series was conceived as a platform to express new ideas and approaches to understanding and solving primary open-angle glaucoma. The authors have attempted to expand levels of knowledge, present new ideas and challenge existing theories. Although the authors have painted a broad picture, the central theme of the book is to ask the right questions and seek the answers for patients with primary open-angle glaucoma.

NEW CONCEPTS IN GLAUCOMA SERIES

This series has been conceived as a recurring project. It is neither book nor journal. Books are infrequently edited and rarely up-to-date for more than a year or two; journals are really devoted to the standard experimental format and no longer permit authors to wander into speculation or lengthy discussions of what might come next. There is room for a plurality of publishing approaches. All of these formats have their place and all have different purposes in moving a field forward. This series is designed to allow us to consolidate new information and hold forth on speculation in glaucoma. It does so in both the basic sciences and clinical sciences. It is our hope that this consolidation of hypotheses and theories, along with identifying new information and new speculation will propel us toward a more rapid cure for glaucoma.


Table of Contents

Table of Contents

Preface

1. Trabecular meshwork cell death in primary open-angle glaucoma
Kelsey A. Green, Beatrice Y.J.T. Yue, John R. Samples, Paul A. Knepper

2. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma
Haiyan Gong, David L. Swain

3. Intraocular pressure control through linked trabecular meshwork and collector channel motion
Murray Johnstone

4. IOP homeostasis – Why most people do not ever develop glaucoma
Ted S. Acott, Mary J. Kelley, Kate E. Keller, Janice A. Vranka, Diala W. Abu-Hassan, Xinbo Li, Mini Aga, John M. Bradley

5. The multiple-hit theory on the pathogenesis of primary open-angle glaucoma
Paul A. Knepper, Kelsey A. Green, John R. Samples

6. Dynamic mechanobiology of conventional outflow
W. Daniel Stamer, Pedro Gonzalez, Mortimer M Civan, Malik Y. Kahook

7. Molecular differences in segmental regions of the trabecular meshwork
Janice A. Vranka, Ted S. Acott

8. Biomechanics and the aqueous humor outflow pathway
Vijay K. Raghunathan, Joshua T. Morgan, Paul Russell

9. Uveoscleral outflow
Sruthi Sampathkumar, Carol B. Toris

10. Autophagy in outflow pathway physiology and pathophysiology
Paloma B. Liton

11. The interleukin-20 (IL-20) story
Kate E. Keller, Mary K. Wirtz

12. Biomarkers in primary open-angle glaucoma
Kelsey A. Green, Paul A. Knepper

13. Family studies of primary open-angle glaucoma
Mary K. Wirtz, John R. Samples

14. Glaucoma and stem cells
Mary J. Kelley, Ted S. Acott, Diala W. Abu-Hassan, Xinbo Li, Kevin Phan, John R. Samples

15. The microenvironment of subconjunctival tissue after glaucoma filtration surgery
Dao-Yi Yu, Stephen J. Cringle, Er-Ning Su

16. Cerebrospinal fluid dynamics and primary open-angle glaucoma
Kelsey A. Green, Nicholas Volpe, Paul A. Knepper

17. Structure-function relationships in the optic nerve head and the consequences of regional pressure disturbances
Chandrakumar Balaratnasingam, William H. Morgan, Min H. Kang, Geoffrey Chan, Dao-Yi Yu

18. The role of blood flow in glaucoma
Scott Wentz, Casey Seizys, Giovanna Guidoboni, Julia C. Arciero, Katherine Hutchins, Brent Siesky, Alon Harris

19. Optic nerve blood flow in primary open-angle glaucoma
Kelsey A. Green, Michael Giovingo, Paul A. Knepper

20. Microvascular disease in glaucoma
Paul A. Knepper, William M. Norkett, Kelsey A. Green, Christopher Wanderling, Paulius V. Kuprys, Michael Giovingo, Angelo P. Tanna, Louis R. Pasquale

21. Laser alteration of the collector channels ostia. Pivotal paradigm shift from laser photocoagulation to laser photostimulation
Giorgio Dorin, Jeffrey K. Luttrull, John R. Samples

22. The 810 Nm I.R. Diode Laser in the pivotal paradigm shift from laser photocoagulation to laser photostimulation
Giorgio Dorin

23. Special consideration for pediatric glaucoma
Peter A. Netland, John R. Samples

24. Novel surgical methods for addressing glaucoma
Arsham Sheybani, Ike K. Ahmed, John Samples

25. Medical device basics
Royce DuBiner, Lane Womack

Index of authors


Kugler Publications
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