Preface

It was a great privilege and honour for me and my deputy chairman Professor Chris Raine to host the 10th International Conference on Cholesteatoma and Ear Surgery (Chole2016) in Edinburgh, Scotland. The Council of the British Society of Otology has helped me tremendously in the preparation of this conference. Over 1000 delegates from 54 countries attended Chole2016 on 5-8 June 2016.

The scientific programme included 12 keynote lectures on the basic science of chronic ear diseases; 23 national symposium; 41 round tables; two live temporal bone dissections; 14 video instructional sessions; 18 free paper sessions and poster presentations. I sincerely thank all the faculties who contributed to the scientific programs and also the delegates who provided a lively discussion during the scientific sessions. It was the exchange of knowledge between the speakers and the delegates that makes the conference so worthwhile to me.

The aim of Chole2016 was to:

1. Bring basic science on chronic ear diseases to the clinicians.
2. Achieve consensus in definitions, classification and staging of cholesteatoma.

The first aim was fulfilled by a scientific programme that focused keynotes sessions on basic sciences. These proved delegates with a fascinating insight into the cellular biology, the role of chronic inflammation, genetic advances, middle ear mechanics/physiology, bacteriology, stem cell research and novel imaging technologies in the context of cholesteatoma. At Chole2016, the joint EAONO/JOS consensus document was presented to the international scientific community for the first time. It led to a lively and productive discussion. A consensus document on classification and staging of cholesteatoma has since been produced.
The Proceedings of Chole2016 is available in paper book as well an-PDF (enhanced PDF with links) and EPUB (optimized for tablets). The electronic versions are freely downloadable for all. If you want a copy (paper book) Kugler Publications can also provide POD (Publishing on Demand) copies for a reasonable price.

Finally, I am very much looking forward to seeing all of you at the 11th Conference in Shanghai in 2020!

Matthew Yung

Table of Contents

Preface
Matthew Yung

The variable clinical presentation of tuberculosis otitis media and the importance of early detection Generoso
T. Abes, Franco Louie LB. Abes, Joselito C. Jamir

Hearing loss and retraction pockets
Roberto Albera, Andrea Canale, Andrea Albera

Dura involvement and lateral skull base reconstruction in cholesteatoma surgery: a retrospective study
A. Anagiotos, D. Schwarz, S. Shabli, A.O. Gostian, K.B. Hüttenbrink

The role of the transotic approach in cases of petrous bone cholesteatoma
Miguel Aristegui, Ignacio Aristegui

Subtotal petrosectomy for cochlear implantation in cases of chronic otitis media
Miguel Aristegui, Ignacio Aristegui, Gracia Aranguez

Skull-base cholesteatoma management options: then and now
Mathieu Forgues, Moisés A. Arriaga

Long-term management of cholesteatoma with labyrinthine destruction, skull base involvement, and intracranial extension
Christina C. Cobb, P. Cody Buchanan, Uresh Patel, Douglas D. Backous

Endoscopic ear surgery: tips
M. Demir Bajin

TB prototype : a perfect complement to traditional teaching of mastoidectomy
D. Bakhos, C. Dorbeau, C. Aussedat

Definitions of disease in eustachian tuboplasty
Mahmood F. Bhutta

Genetics of cholesteatoma
Mahmood F. Bhutta, Peter Prinsley, Carl Philpott, Barbara Jennings

Mastoidectomy reconstruction with titanium sheeting
Bruce Black

Keyhole cochlear implant surgery: adaptation for Med El Soundbridge and Bonebridge devices
Bruce Black

Prognostic factors in paediatric cochlear implantation: definition, location, evaluation
Jane Black, Bruce Black

Integrating endoscopy into everyday otology practice
Jose Carlos Casqueiro

Bone conduction implants in pediatric cholesteatoma management
Stephen P. Cass, Gregory C. Allen, Kenny H. Chan

Managing cholesteatoma: Something old, something new, and something borrowed
Sujana S. Chandrasekhar

Bone cements for mastoid/posterior canal wall reconstruction
Sujana S. Chandrasekhar

Surfactant and Eustachian tube dysfunction/otitis media
Sujana S. Chandrasekhar, Alan J. Mautone

Middle ear pressure maintenance: (1) A concert played by many instruments; (2) Pathology as compensation
Udi Cinamon

Studies by nature of Eustachian tube dysfunction: a preliminary report
Udi Cinamon, Hussein Amer, Avraham Lazary, Dov Albukrek, Tal Marom

Facial paralysis in chronic otitis media
Vincent C. Cousins

Middle ear gas exchange problems in otitis media with effusion and acquired cholesteatoma
Zsuzsanna Csakanyi, Gabor Katona

Current trends in managing complications of chronic otitis media with cholesteatoma
Jyoti P. Dabholkar, Jaini Lodha, Nitish Virmani

The surgical management of temporal bone cholesteatoma involving the jugular foramen
Chunfu Dai

Past, present and future treatment of biofilms in otitis media
Mat Daniel

Hydroxyapatite cement for hearing reconstruction
Stefan Delrue, Joost van Dinther, Andrzej Zarowski, Thomas Somers, Erwin Offeciers

3D-CT analysis of the FMT angle to the RW/OW after VSB surgery
Katsumi Doi, Takeshi Fujita, Kazuya Saito, Kumi Kohama, Daisuke Nagatomi

Hacettepe cartilage slicer: a novel cartilage slicer and its performance tests
Onur Ergun, Munir Demir Bajin, Mustafa Fevzi Sargon, Levent Sennaroglu

Mastoid obliteration with homologous bone graft
Anna Carolina de Oliveira Fonseca, José Celso Rodrigues de Souza, Eloisa Maria Mello Santiago Gebrim, Luiz Augusto Ubirajara Santos, Ricardo Ferreira Bento

Cadaver dissection as a teaching tool in ear surgery
V. Franco-Vidal

Ten-year outcomes with the shape memory Nitinol stapes prosthesis
Rebecca L. Heywood, Mark E. Quick, Marcus D. Atlas

Removal of cholesteatoma matrix from inner ear fistula
Harukazu Hiraumi

Which device ‒ when and why? The controversial role of bone conduction hearing devices in the rehabilitation of unilateral sensorineural hearing loss
W. Hodgetts, D.P. Morris, J. Ray, M.K.S. Hol

Turner syndrome: Translational research concerning ear and hearing. A summery from recent years
Malou Hultcrantz

Predictive factors for recurrent cholesteatoma in children
Adrian James

Tympanoplasty using medio-lateral graft for anterior or subtotal tympanic membrane perforation
Timothy T. K. Jung

Overview of biofilms and otitis
Romain Kania

Hearing reconstruction: how I do it. A step-by-step ossicular chain reconstruction
Romain Kania, Benjamin Verillaud, Philippe Herman

Regulation of osteoclasts is required to maintain morphology and function of ossicles in middle ear; clinical implication of cholestatoma
Sho Kanzaki, Kaoru Ogawa, Koichi Matsuo

Where is it safe to leave residual vestibular schwannoma during surgery?
Anand V. Kasbekar, Guleed H Adan, Alaina Beacall, Ahmed M. Youssef, Catherine E. Gilkes, Tristram H. Lesser

Bony obliteration technique (BOT) surgery in paediatric cholesteatoma cases
Gabor Katona

Endoscopic management of cholesteatoma with Khan’s Endoholder
Department Of Otorhinolaryngology, M.I.M.E.R. Medical College, Pune, India

Current trends of cholesteatoma surgery in Japan: results from the Japan Otological Society Registry using 2015 JOS Staging and Classification System
Manabu Komori, Tetsuya Tono, Masafumi Sakagami, Hiromi Kojima, Naohito Hato, Yutaka Yamamoto, Keiji Matsuda, Yuka Morita, Sho Hashimoto

Mastoid obliteration six-years follow-up results. European trend, local peculiarities
Sergey Kosyakov, Ekaterina Pchelenok

Management of the facial nerve in cholesteatoma surgery: multidisciplinary approach in a Facial Paralysis Unit
Luis Lassaletta, Julio Peñarrocha, Teresa González, Susana Moraleda, Javier Gavilán

The keratinocyte in health and disease
Irene Leigh

Introducing the ‘ChOLE’ Classification
Thomas E Linder,Shankar Shah, Christof Röösli, Alex M Huber, Nue Milici

DWI imaging in extensive petrous bone cholesteatoma
Simon K.W. Lloyd, Hannah North, Andrew T. King, Scott Rutherford, Charlotte Hammerbeck-Ward, Simon Freeman

Encephalocele and brain herniation from previous mastoid surgery
Simon K.W. Lloyd, Hannah North, Andrew T. King, Scott Rutherford, Charlotte Hammerbeck-Ward, Simon Freeman

Practicality analysis of JOS staging system for congenital cholesteatoma: Japan Multicenter study (2009-2010)
Yuka Morita, Tetsuya Tono, Yutaka Yamamoto, Hiromi Kojima, Masafumi Sakagami, Yasuo Mishiro, Taeko Okuno, Yasuyuki Hinohira, Keiji Matsuda, Sho Hashimoto

Surgery of cholesteatoma in pediatric age: assessment of combined micro-endoscope approach
N. Nassif, T. Sorrentino, S. Zorzi, L.O. Redaelli De Zinis

Cochlear implantation in chronic otitis media
Abdullah Dalgic, Tolgahan Catli, Deniz T. Edizer, Gorkem Atsal, Levent Olgun

Approach to petrous bone cholesteatoma
Tolgahan Catli, Deniz Tuna Edizer, Abdullah Dalgic, Cagri Celik, Levent Olgun

Active middle ear implants in chronic otitis media
Levent Olgun, Deniz T. Edizer, Abdullah Dalgic, Tolgahan Catli, Cagri Celik

Adhesive otitis media and ossiculoplasty
Kadir Serkan Orhan, Beldan Polat, Mehmet Çelik, Hakan Avcı, İbrahim Yağcı, Yahya Güldiken

The COMQ-12 and COMBI questionnaires for the assessment of cholesteatoma surgery outcome
John S. Phillips

Diagnosis, classification and surgical management of petrous bone cholesteatomas: Review of 200 consecutive patients
Sampath Chandra Prasad, Gianluca Piras, Enrico Piccirillo, Mario Sanna

Subtotal petrosectomy – Surgical technique, indications, outcomes and comprehensive review of literature
Sampath Chandra Prasad, Valeria Roustan, Enrico Piccirillo, Mario Sanna

Beyond middle ear
Livio Presutti, Marco Bonali

Retraction pocketS – endoscopic approach
Livio Presutti, Marco Bonali

The genetics of cholesteatoma project
Peter Prinsley, Carl Philpott, Barbara Jennings, Mahmood Bhutta

Surgical technique for BONEBRIDGE implantation in young children with previous mastoidectomy due to chronic suppurative otitis media
Ángel Ramos-Macias, Daniel Perez-Plasencia, Elena Muñoz Pascual, Marta Bastarrica Martí, Angel Osorio Acosta

Canal-wall-down mastoidectomy with and without autologous bone obliteration: A comparison of results in adults
Luca O. Redaelli de Zinis, Francesco Mancini, Tommaso Sorrentino, Daniela Tonni

First experience with the ChOLE classification in combination with a QoL questionnaire
Christof Röösli, David Bächinger, Thomas E Linder, Alex M Huber

Pathogenesis of cholesteatoma: Changing concepts
Letícia P.S. Rosito, M.N.L. Silva, I. Canali, F.A. Selaimen, S.S. Costa

Cholesteatoma in children ‒ the profile of paediatric and adult cholesteatoma presenting in a secondary and tertiary care setting
Robert Nash, Shakeel R. Saeed

Assessment of vestibular function in patients with chronic middle ear dysfunction using vhit and vemp testing
J.S. Sandhu, M. Yung, J. Parker-George, B. Kearney, J. Ray

CT vs CT-MRI Fusion imaging in preoperative mastoid assessment for cholesteatoma: Implications for endoscopic ear surgery
Alexander J. Saxby, Laughlin Dawes, Christina Cheng, Samantha Wills, Nicholas Jufas, Jonathan Kong, Nirmal Patel, Simon Greenberg

Primary obliteration of the mastoid cavity in cholesteatoma surgery
Lars P. Schousboe

Cholesteatoma in the developing world, what do we know, and what can we do?
Michael C.F. Smith

MRI evaluation of endolymphatic hydrops for middle ear surgery
Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto

Alterations of MYC locus in cholesteatoma as an analogy to neoplastic transformation
Krzysztof Szyfter, Małgorzata Jarmuż-Szymczak, Wojciech Gawęcki, Magdalena Kostrzewska-Poczekaj, Witold Szyfter

Open mastoidectomy and soft-wall reconstruction
Haruo Takahashi

Clinical implication of the middle-ear pressure-regulation functions
Haruo Takahashi

Clinical incidence and management of otitis media with effusion in Vietnamese children
Tran Le Thuy, Huynh Ba Tan

Introduction of the Japan Otological Society work on classification and staging of cholesteatoma: the Nationwide Survey of cholesteatoma surgical cases in Japan
Tetsuya Tono, Masafumi Sakagami, Hiromi Kojima, Yutaka Yamamoto, Keiji Matsuda, Manabu Komori, Naohito Hato, Yuka Morita, Sho Hashimoto; The Committee on Nomenclature of the Japan Otological Society

Poverty and ethnicity in the aetiology of cholesteatoma; Preliminary data from New Zealand’s North Central Region
S.C. Toynton, D. Schreiber

Epidemiology of pediatric otitis media in Taiwan
Mao-Che Wang

Practicality analysis of JOS staging system for cholesteatoma secondary to a pars tensa perforation: Japan Multicenter Study (2009-2010)
Yutaka Yamamoto, Tustuya Tono, Hiromi Kojima, Yuka Morita, Masafumi Sakagami, Yasuo Mishiro, Taeko Okuno, Yasuyuki Hinohira, Keiji Matsuda, Sho Hashimoto

Inflammatory, invasive and neoplastic features of primary and secondary cholesteatomas: Immunohistochemical and histological findings
Nadir Yildirim, Ayşe Nur Deger, Onur Erdogan, Semra Külekci

Simple underlay myringoplasty
Yu Yuasa