Current Opinions in the Kyoto Cornea Club II
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Publication details: Book. 1998. x and 107 pages. Publication date: 1998-02-27. 48 figures of which 8 full color, and 15 tables. Paperbound.
Also available as ebook
Since the first volume was published, significant advances have been made in corneal molecular and cellular biology and in the physiology of various corneal disorders, their healing processes and optimal management. Two papers deserve special attention: one by Roger W. Beuerman on the interactions between the cornea and the lacrimal gland and the other by Yoshihide Tsujimoto on the molecular mechanism of cell death, focusing on the Bc1-2 and ICE family protease. The remaining papers deal with issues of neuroparalytic keratitis, corneal wound healing and SPARC, genetic influences, corneal transplantation, herpetic infections, the effect of metalloproteases on the corneal epithelium, IL-8 and RANTE5 generation from the corneal epithelium, all of which topics are at the forefront of development in their field.
The present volume represents the proceedings of the Second Annual Meeting of the Kyoto Cornea Club, held on December 6-7, 1996. This built upon the strong base laid down by the first meeting in which corneal specialists and invited lecturers provided a 'state-of-the-art' of research and development in this field. Since the first meeting, there have been significant advances, with rapid progress being made into corneal molecular, cellular biology and physiology in various corneal disorders, their healing processes and optimal management. To provide a comprehensive and informative overview, while allowing for interactive sessions with stimulating discussions, a program was devised which provided participants with topics which were at the forefront of developments in their field. There were two guest lectures presented by world renowned experts. The first looked at interactions between the cornea and the lachrymal gland and was given by Dr. Beuerman, LSU Eye Center, New Orleans, U.S.A. The second was presented by Prof. Tsujimoto, Biomedical Research Center, Osaka University Medical School, who spoke on the molecular mechanism of cell death focusing on the Bcl-2 and ICE Family protease. In addition, there were two symposia which addressed the issues of neuroparalytic keratitis, corneal wound healing and SPARC, genetic influences, corneal transplantation, herpetic infections, the effect of metalloproteases on the corneal epithelium, IL-8 and RANTES generation from corneal epithelium, as well as other clinically important issues.
This second volume brings together in one issue all of the material presented at this meeting, allowing those interested to use the book as an update on latest developments as well as a reference guide which they can 'dip' into at their leisure. We would like to thank all of the participants for the excellence of their presentations, the depth of their knowledge and willingness to share this with those attending the meeting. Their commitment to the ongoing developments occurring in the field of corneal disorders was demonstrated throughout this meeting, and their enthusiasm helped generate such a positive atmosphere that we are sure all attending felt enthused to continue learning more about this rapidly expanding field. We hope you enjoy reading this book as much as we have enjoyed the process leading up to it.
Shigeru Kinoshita and Yuichi Ohashi
Table of Contents
List of Club Members
List of Contributors
Interactions between lacrimal function and the ocular surface
Roger W. Beuerman, Dmitri Y Maitschouk, Ray J. Varnell and Lia Pedroza-Schmidt
Signal transduction induced in human conjunctival epithelial cells by TNF-α
Kazamu Fukagawa, Kazito Tsubota, Shigeto Simmura, Ichiro Saito, Yoshihisa Oguchi and Hirohisa Saito
Matrix metalloproteinases in degradation and remodeling of the
corneal epithelial basement membrane
Masao Matsubara and M. Elizabeth Fini
Pathogenesis of keratoconus
The role of cell adhesion molecules and cytokines in allograft rejection
after penetrating keratoplasty in mice
Tadahiko Tsuru, Junko Hori and Satoru Yamagami
Pathogenesis of ocular herpes infection
Herpes simplex virus latency in the cornea
The mechanism of neurotrophic keratitis
The role of SPARC in corneal wound healing
Hiroshi Mishima, Tsuyoshi Hibino, Hidenori Hara and Toshifumi Otori
Compiling a gene expression profile and discovering genes abundantly and specifically expressed in human corneal epithelium
Molecular mechanism of cell death
Index of authors